Isolation, communication difficulties, reduced alertness — hearing impairment or loss is a real challenge in daily life. Over time, it can also become a risk factor for cognitive decline. A team from the University of Geneva (UNIGE) analysed data from 33,000 older adults across Europe to examine the combined impact of hearing loss and loneliness
Identification of dysregulated expressed genes As the work flow shown in Fig. S1, three GEO data sets (GSE61145, GSE34198, and GSE66360) were included in this study. A total of 697, 163, and 734 up-regulated and 679, 72, and 741 downregulated genes were obtained in GSE34198, GSE61145, and GSE66360 respectively (Fig. 1A). According to the heatmap shown
In light of reports from the White House that President Donald J. Trump has been diagnosed with Chronic Venous Insufficiency (CVI), the American Heart Association is sharing important information on the condition and its association with cardiovascular risk factors, disease and increased risk of death. According to the Association, the world’s leading nonprofit organization focused
Study population Portable EEG data were obtained from 294 participants (122 healthy volunteers (HVs) and 172 patients) at the Osaka University Hospital. The HVs were community-dwelling older adults and selected based on the following inclusion criteria: (1) no history of neurological or psychiatric diseases, (2) no history of severe head injury or alcohol/drug abuse, and
Participants and study design The data was from a follow-up study of college students at Binzhou Medical University in Yantai, Shandong Province20,21. The first wave of data was collected between August 23 and September 23, 2019. Baseline information including questionnaires and blood samples22. The questionnaire contained the following: Demographic data (age, sex, BMI). Lifestyle information
Participants Participants were recruited between August 2023 and the time of statistical analysis through offline advertisements at Beijing Huilongguan Hospital. A total of 22 individuals with schizophrenia and 22 healthy controls matched for gender, age, and educational level were initially enrolled. Due to excessive head motion (translation > 3 mm or rotation > 3°), imaging data from 2 patients and
Patient cohorts This multicenter study included retrospective development and validation of the GAS platform, followed by a prospective validation to assess its generalizability. The Generation module was trained using retrospectively collected data from the Internal GZCC. External validation involved six independent cohorts from JMCH, HZCH, DGPH, JMPH, ZSZL, and TCGA. A prospective cohort was enrolled
E. coli outbreaks in romaine lettuce have long been a public health concern. and now a new Cornell University paper suggests that a combination of efforts in the field, and even postharvest techniques, can minimize risk to human health. Co-authored by Renata Ivanek, a professor in the department of population medicine and diagnostic sciences, and
Molecular Docking and molecular dynamics simulations Before molecular docking, an open conformational state of the SARS-CoV-2 PLpro 3D structure (PDB ID: 6WX4), regarding the BL2 (residues Gly266–Gly271) access loop to the active site, was characterized by a short MD simulation, measuring inter-residue distances through frame-by-frame analysis. This protein open conformational state is crucial to allow
From low-carb ice cream to keto protein bars to “sugar-free” soda, the decades-old sweetener erythritol is everywhere. But new University of Colorado Boulder research shows the popular sugar substitute and specialty food additive comes with serious downsides, impacting brain cells in numerous ways that can boost risk of stroke. The study was published in the
